Physiological genomic analysis of Lvm-1 - a genetic locus that determines left ventricular mass

Lvm-1（决定左心室质量的遗传位点）的生理基因组分析

• 批准号: nhmrc : 208973
• 负责人: Prof Stephen Harrap
• 金额: $ 23.77万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/physiological-genomic-analysis-ventricular-mass/97488
• 关键词: Physiological; genomic; analysis; Lvm; genetic

As many as one in ten healthy individuals have big hearts. Careful scientific investigation has revealed that the bigger one's heart, the greater the risk of dying from cardiovascular disease. This is true even in the absence of known causes of heart disease. Unlike high blood pressure or cholesterol, the size of the heart is not easily measured and enlargement often goes undetected. We were among the first internationally to discover genetic clues to enlarged hearts. We identified regions on rat chromosomes that harbour the gene or genes that influence heart size. The aim of these studies is to identify the exact gene responsible and to understand how that gene produces its effects. The experiments involve testing DNA samples already obtained from many hundreds of rats and breeding animals to study the consequences of the genetic abnormality in greater detail. The experiments are critical steps towards the prevention of big hearts and their complications in humans. In time, genetic tests will offer earlier detection and facilitate targeted and tailored treatments.

多达十分之一的健康人都有大心脏。仔细的科学调查表明，一个人的心脏越大，死于心血管疾病的风险就越大。即使在没有已知心脏病原因的情况下也是如此。与高血压或胆固醇不同的是，心脏的大小不容易测量，而且通常不会被发现。我们是国际上最早发现心脏变大的基因线索的人之一。我们在大鼠染色体上发现了包含影响心脏大小的基因或基因的区域。这些研究的目的是确定负责的确切基因，并了解该基因如何产生其影响。这些实验包括测试已经从数百只老鼠和繁殖动物身上获得的DNA样本，以更详细地研究基因异常的后果。这些实验是预防人类大心脏及其并发症的关键步骤。随着时间的推移，基因检测将提供更早的检测，并促进有针对性和量身定制的治疗。