Physiology of a mutant angiotensin receptor associated with cardiac hypertrophy

与心脏肥大相关的突变血管紧张素受体的生理学

• 批准号: nhmrc : 454626
• 负责人: Prof Stephen Harrap
• 金额: $ 19.58万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/physiology-mutant-angiotensin-cardiac-hypertrophy/82148
• 关键词: Physiology; mutant; angiotensin; receptor; associated

As many as one in ten healthy individuals have hearts that are bigger than normal. Careful scientific investigation has revealed that the bigger one's heart, the greater the risk of dying from cardiovascular disease. This is true even in the absence of known causes of heart disease. Unlike high blood pressure or cholesterol, the size of the heart is not easily measured and enlargement often goes undetected. We were among the first internationally to discover genetic clues to enlarged hearts. We identified a region on a rat chromosome that influences heart size and we have now discovered abnormalities in a key gene in this region. These changes alter the function of a cellular protein that mediates hormonal effects on heart cell size. Our team of experts will employ the most modern technologies to understand exactly how this altered protein affects heart cell function and growth. We have a unique opportunity to exploit this experiment of nature to help us devise new means of preventing big hearts and their fatal complications in humans.

多达十分之一的健康人的心脏比正常人大。仔细的科学调查表明，一个人的心脏越大，死于心血管疾病的风险就越大。即使在没有已知心脏病原因的情况下也是如此。与高血压或胆固醇不同的是，心脏的大小不容易测量，而且通常不会被发现。我们是国际上最早发现心脏变大的基因线索的人之一。我们在老鼠的染色体上发现了一个影响心脏大小的区域，现在我们发现了这个区域的一个关键基因的异常。这些变化改变了调节激素对心脏细胞大小影响的细胞蛋白的功能。我们的专家团队将采用最先进的技术来准确了解这种改变的蛋白质是如何影响心脏细胞功能和生长的。我们有一个独特的机会来利用这个自然实验来帮助我们设计新的方法来防止人类心脏变大及其致命的并发症。