Piezo2 and Pain - Is there a role for Piezo2 in mechanically induced bone pain?

Piezo2 和疼痛 - Piezo2 在机械引起的骨痛中是否起作用？

• 批准号: nhmrc : 1138756
• 负责人: A/Pr Stuart Mazzone
• 金额: $ 36.77万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/piezo2-pain-role-bone-pain/1318849
• 关键词: Piezo2; Pain; there; role; mechanically

Pain associated with bone marrow edema, osteoarthritis, bone cancer and fracture puts a significant burden on individuals, society, and the health care system in Australia. A dominant feature of these includes mechanical disturbances of the bone, and this is a trigger for the pain. In this study, we will determine if a newly discovered mechanically gated ion channel (Piezo2) is a key contributor to mechanically induced bone pain and could be a target for development of drugs to treat it.

在澳大利亚，与骨髓水肿、骨关节炎、骨癌和骨折相关的疼痛给个人、社会和医疗保健系统带来了沉重的负担。这些疾病的一个主要特征包括骨骼的机械紊乱，这是疼痛的诱因。在这项研究中，我们将确定新发现的机械门控离子通道（Piezo2）是否是机械诱导骨痛的关键因素，并可能成为开发治疗骨痛的药物的目标。