Plasma exchange and glucocorticoids in anti-neutrophil cytoplasm antibody associated systemic vasculitis: a randomised controlled trial (PEXIVAS Australia)

血浆置换和糖皮质激素治疗抗中性粒细胞胞质抗体相关的系统性血管炎：一项随机对照试验（PEXIVAS Australia）

• 批准号: nhmrc : 1086192
• 负责人: A/Pr Carmel Hawley
• 金额: $ 28.01万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/plasma-exchange-glucocorticoids-pexivas-australia/519123
• 关键词: Plasma; exchange; glucocorticoids; anti; neutrophil

ANCA-associated vasculitis is a life-threatening disease. The PEXIVAS trial will investigate whether plasma exchange, in addition to immunosuppressive therapy and glucocorticoids, will reduce death and the development of severe kidney failure due to this disease. Additionally, the project will also look at whether using a reduced dose of glucocorticoids is just as effective as larger doses in lessening the infectious complications of treatment.

ANCA相关性血管炎是一种危及生命的疾病。PEXIVAS试验将调查血浆置换，除了免疫抑制治疗和糖皮质激素，是否会减少死亡和严重肾衰竭的发展，由于这种疾病。此外，该项目还将研究使用减少剂量的糖皮质激素是否与大剂量的糖皮质激素一样有效，以减少治疗的感染并发症。