Platelet Derived Growth Factor Mediated Activation and Rejuvenation of Endogenous Cardiac Stem Cells

血小板衍生生长因子介导的内源性心脏干细胞的激活和再生

• 批准号: nhmrc : GNT1114472
• 负责人: Dr Sujitha Thavapalachandran
• 金额: $ 6.82万
• 依托单位: University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/platelet-derived-growth-stem-cells/1346907
• 关键词: Platelet; Derived; Growth; Factor; Mediated

The burden of heart failure is underpinned by the heart’s limited capacity for self-repair after injury. Recent evidence shows that PDGF can improve heart function by activating and rejuvenating resident heart stem cells. This project will build on over a decade of preliminary work in mice, validating our results in a preclinical large animal model. Outcomes of this project include expedited progression of this promising therapy where thousands of heart failure patients could one-day benefit.

心力衰竭的负担是由心脏在受伤后有限的自我修复能力支撑的。最近的证据表明，PDGF可以通过激活和恢复驻留的心脏干细胞来改善心脏功能。该项目将建立在十多年的小鼠前期工作的基础上，在临床前的大型动物模型中验证我们的结果。该项目的成果包括加快了这一有希望的治疗方法的进展，数千名心力衰竭患者可能会在一天内受益。