Pluripotent Stem Cell Derived Cardiomyocytes: Improving Electrical Stability and Quantifying Functional Improvements

多能干细胞衍生的心肌细胞：提高电稳定性并量化功能改善

• 批准号: nhmrc : 1126276
• 负责人: A/Pr Pramesh Kovoor
• 金额: $ 45.76万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pluripotent-stem-cell-functional-improvements/947758
• 关键词: Pluripotent; Stem; Cell; Derived; Cardiomyocytes

Cardiovascular diseases and heart failure rates are increasing worldwide. This is largely a result of the heart’s limited capacity for self-repair. Stem cells now provide an exciting potential novel therapy. We have recently demonstrated the feasibility of this therapy in a preclinical model of heart attack. Nevertheless, further work is required before human clinical trials can take place. This project will dismantle barriers preventing progression to these clinical trials.

全世界心血管疾病和心力衰竭的发病率正在上升。这主要是由于心脏的自我修复能力有限。干细胞现在提供了一种令人兴奋的潜在新疗法。我们最近在心脏病发作的临床前模型中证明了这种疗法的可行性。然而，在进行人体临床试验之前，还需要进一步的工作。这个项目将消除阻碍这些临床试验进展的障碍。