Population genomics of Plasmodium falciparum surface antigen genes

恶性疟原虫表面抗原基因的群体基因组学

• 批准号: nhmrc : 488221
• 负责人: A/Pr Alyssa Barry
• 金额: $ 25.69万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/population-genomics-plasmodium-antigen-genes/100617
• 关键词: Population; genomics; Plasmodium; falciparum; surface

Like most other organisms, each malaria parasite has unique characteristics. A malaria vaccine will need to incorporate these differences to be effective against all parasites in a population. This project will measure the variability and fluctuations of eight of the most promising vaccine targets in a number of natural malaria populations. With this knowledge, a vaccine that is effective against all parasites in the population can be developed and its future success maintained.

像大多数其他生物一样，每种疟原虫都有独特的特征。疟疾疫苗需要结合这些差异，才能有效对抗人群中的所有寄生虫。该项目将测量8个最有希望的疫苗目标在一些自然疟疾人群中的变异性和波动。有了这些知识，就可以开发出一种对人群中所有寄生虫都有效的疫苗，并保持其未来的成功。