Var gene diversity and naturally acquired immunity to malaria

Var基因多样性和对疟疾的自然获得性免疫力

• 批准号: nhmrc : 1005653
• 负责人: A/Pr Alyssa Barry
• 金额: $ 27.38万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/var-gene-diversity-immunity-malaria/109102
• 关键词: Var; gene; diversity; naturally; acquired

In areas where malaria is common, people develop natural immunity to the disease albeit very slowly due to the many parasite strains that circulate. The project will use protein microarrays to investigate the patterns by which antibodies are acquired to the majority of strains. This will reveal how antibodies are acquired with age and which are associated with protection against malaria symptoms. The research aims to identify biomarkers of malaria immunity and may lead to new vaccine candidates.

在疟疾常见的地区，人们对这种疾病产生自然免疫力，尽管由于传播的许多寄生虫菌株非常缓慢。该项目将使用蛋白质微阵列来研究获得对大多数菌株的抗体的模式。这将揭示抗体是如何随着年龄的增长而获得的，以及哪些抗体与预防疟疾症状有关。这项研究旨在识别疟疾免疫的生物标记物，并可能导致新的候选疫苗。