Post-transcriptional regulation of plasminogen activator inhibitor 2 gene expression

纤溶酶原激活剂抑制剂2基因表达的转录后调控

• 批准号: nhmrc : 491151
• 负责人: Dr Stan Stasinopoulos
• 金额: $ 33.93万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/post-transcriptional-regulation-gene-expression/81737
• 关键词: Post; transcriptional; regulation; plasminogen; activator

Plasminogen activator inhibitor type 2 (PAI-2) is a protease inhibitor that has intracellular and extracellular functions. The PAI-2 gene is highly regulated at the level of PAI-2 mRNA stability. We have identified regions within the PAI-2 transcript essential for this regulation and a number of novel proteins that engage these regions. This project is aimed at understanding how these and other proteins control PAI-2 expression at the mRNA level.

纤溶酶原激活物抑制物2(PAI-2)是一种具有细胞内和细胞外功能的蛋白水解酶抑制物。PAI-2基因在PAI-2mRNA稳定性水平上受到高度调控。我们已经确定了PAI-2转录本中对这种调控至关重要的区域，以及一些参与这些区域的新蛋白质。该项目旨在了解这些蛋白质和其他蛋白质如何在mRNA水平上控制PAI-2的表达。