Preventing impaired beta-cell plasticity, insulin secretion and diabetes after IUGR

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Babies who are born small are at increased risk of later diabetes, partly because restricting growth before birth also impairs development of insulin-secreting cells in the pancreas, impairing later insulin secretion and contributing to diabetes. We will define the mechanisms underlying impaired insulin secretion in a well-established animal model of fetal growth restriction. Importantly, we will also test interventions to improve insulin secretion after intrauterine growth restriction.