Progressive aphasia and amyloid deposition: a multidisciplinary approach to improving dementia diagnosis

进行性失语和淀粉样蛋白沉积：改善痴呆诊断的多学科方法

• 批准号: nhmrc : 630489
• 负责人: A/Pr Victor Villemagne
• 金额: $ 35.22万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/progressive-aphasia-amyloid-dementia-diagnosis/78146
• 关键词: Progressive; aphasia; amyloid; deposition; multidisciplinary

We aim to understand the role of amyloid deposition in the genesis of symptoms in Alzheimer's disease. Patients presenting with progressive deterioration of language (aphasia) some of whom are known to have Alzheimer's disease will be studied using brain imaging techniques, including a PET method (PiB) that labels amyloid in vivo, and to compare imaging changes with a range of language assessments. This will improve the early diagnosis and management of patients with progressive aphasia.

我们的目的是了解淀粉样蛋白沉积在阿尔茨海默病症状发生中的作用。出现进行性语言退化（失语症）的患者（其中一些已知患有阿尔茨海默病）将使用脑成像技术进行研究，包括PET方法（PiB），该方法在体内标记淀粉样蛋白，并将成像变化与一系列语言评估进行比较。这将改善进行性失语症患者的早期诊断和管理。