Brain iron imaging for Alzheimer’s disease (AIBL-ADIRON study)

阿尔茨海默病的脑铁成像（AIBL-ADIRON 研究）

• 批准号: nhmrc : GNT1101533
• 负责人: A/Pr Victor Villemagne
• 金额: $ 122.79万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/brain-iron-imaging-adiron-study/1346161
• 关键词: Brain; iron; imaging; Alzheimer; disease

Iron accumulation in the brain is linked to Alzheimer's disease. New Magnetic Resonance Imaging scans allow us to painlessly image the brain and measure its size and iron concentration. In this project more than 330 volunteers over 60 will be scanned every 18 months over 3 years. We will determine if those subjects with higher iron concentration in their brain have a smaller brain and worse performance in this period. This will confirm a role for iron in Alzheimer's as a new treatment target.

大脑中的铁积累与阿尔茨海默病有关。新的磁共振成像扫描使我们能够无痛地成像大脑并测量其大小和铁浓度。在这个项目中，330多名60岁以上的志愿者将在3年内每18个月接受一次扫描。我们将确定那些大脑中铁浓度较高的受试者在这一时期是否大脑更小，表现更差。这将证实铁在阿尔茨海默氏症中作为一个新的治疗靶点的作用。