In vivo tau imaging in Alzheimer’s disease and other dementias

阿尔茨海默病和其他痴呆症的体内 tau 成像

• 批准号: nhmrc : 1044361
• 负责人: A/Pr Victor Villemagne
• 金额: $ 35.94万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/vivo-tau-imaging-disease-dementias/111656
• 关键词: vivo; tau; imaging; Alzheimer; disease

Alteration of the normal protein tau leads to its deposition inside the brain cells leading to their death. These deposits have been well characterized and they are associated with cognitive impairment. We propose to study tau deposits in vivo in humans using positron emission tomography (PET) and assess its association with cognition and other signs of neurodegeneration

正常蛋白tau的改变导致其沉积在脑细胞内，导致其死亡。这些沉积物已被很好地表征，它们与认知障碍有关。我们建议使用正电子发射断层扫描（PET）研究人类体内的tau蛋白沉积，并评估其与认知和其他神经退行性疾病体征的相关性