Proline-rich host defense peptide analogues as new antibiotics against MDR bacteria

富含脯氨酸的宿主防御肽通常来自昆虫，具有多峰抗菌作用。对于日益减少的抗生素武库来说，它们是一种新颖的潜在关键补充，以应对全球耐药感染的威胁。该项目将开发我们的先导肽的多聚体类似物作为新型抗生素，并将扩大澳大利亚的知识库和研究能力，提供高质量的培训，并加强国际研究合作。

Proline-rich host defense peptides, typically derived from insects, possess multimodal antibacterial actions. They are a novel and potentially crucial addition to the dwindling armoury of antibiotics to address the global threat of drug-resistant infections. This project will develop multimeric analogues of our lead peptides as novel antibiotics and will expand Australia’s knowledge base and research capability, provide high quality training and enhance international research collaboration.