Proline-rich host defense peptide analogues as new antibiotics against MDR bacteria

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Proline-rich host defense peptides, typically derived from insects, possess multimodal antibacterial actions. They are a novel and potentially crucial addition to the dwindling armoury of antibiotics to address the global threat of drug-resistant infections. This project will develop multimeric analogues of our lead peptides as novel antibiotics and will expand Australia’s knowledge base and research capability, provide high quality training and enhance international research collaboration.