Proline-rich host defense peptide analogues as new antibiotics against MDR bacteria

富含脯氨酸的宿主防御肽类似物作为针对 MDR 细菌的新型抗生素

• 批准号: nhmrc : GNT1158841
• 金额: $ 61.08万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/proline-rich-host-mdr-bacteria/1379050
• 关键词: Proline; rich; host; defense; peptide

Proline-rich host defense peptides, typically derived from insects, possess multimodal antibacterial actions. They are a novel and potentially crucial addition to the dwindling armoury of antibiotics to address the global threat of drug-resistant infections. This project will develop multimeric analogues of our lead peptides as novel antibiotics and will expand Australia’s knowledge base and research capability, provide high quality training and enhance international research collaboration.

富含脯氨酸的宿主防御肽，通常来源于昆虫，具有多模式抗菌作用。它们是一种新型的，可能是对日益减少的抗生素库的重要补充，以应对耐药感染的全球威胁。该项目将开发我们的先导肽的多聚体类似物作为新型抗生素，并将扩大澳大利亚的知识基础和研究能力，提供高质量的培训并加强国际研究合作。