Proteomics of arthritis: Exploring mechanisms of cartilage degradation and biomarker identification

关节炎的蛋白质组学：探索软骨降解的机制和生物标志物识别

• 批准号: nhmrc : 491237
• 负责人: Prof Jeffrey Gorman
• 金额: $ 39.48万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/proteomics-arthritis-exploring-biomarker-identification/78389
• 关键词: Proteomics; arthritis; Exploring; mechanisms; cartilage

Arthritis is a major clinical and socio-economic problem. Arthritis involves the destruction of cartilage in joints. However, the mechanisms of initiation and progression of cartilage destruction remain poorly understood. Our studies will use new proteomic approaches to identify the changes in protein synthesis and degradation in mouse models of arthritis. This will provide critical information on disease mechanisms and for the development of diagnostic biomarkers and therapeutic approaches

关节炎是一个主要的临床和社会经济问题。关节炎涉及关节软骨的破坏。然而，软骨破坏的发生和发展机制仍然知之甚少。我们的研究将使用新的蛋白质组学方法，以确定蛋白质合成和降解的变化，在小鼠模型关节炎。这将为疾病机制以及诊断生物标志物和治疗方法的发展提供关键信息