Allosteric modulation and biased signalling at the calcium-sensing receptor

钙敏感受体的变构调节和偏向信号传导

• 批准号: nhmrc : 1026962
• 负责人: Dr Katie Leach
• 金额: $ 42.42万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/allosteric-modulation-biased-sensing-receptor/110529
• 关键词: Allosteric; modulation; biased; signalling; calcium

The calcium-sensing receptor is a major target for the treatment of endocrine and bone disorders. However, the development of drugs for this receptor is challenging due to limited understanding of potential sites of drug interaction and how individual drugs may differentially change signalling from the receptor. This project will address these critical knowledge gaps, which may allow for improved therapeutic outcomes.

钙敏感受体是治疗内分泌和骨骼疾病的主要靶点。然而，由于对药物相互作用的潜在部位以及单个药物如何差异地改变来自该受体的信号的了解有限，针对该受体的药物的开发是具有挑战性的。该项目将解决这些关键的知识差距，这可能会改善治疗结果。