Engendering biased signalling at the human calcium sensing receptor (CaSR) to correct pathophysiology
Engendering biased signalling at the human calcium sensing receptor (CaSR) to correct pathophysiology
在人类钙敏感受体 (CaSR) 上产生偏向信号以纠正病理生理学
批准号：
nhmrc : 1085143
负责人：
Dr Katie Leach
金额：
$42.27万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2015
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2015-01-01 至 2018-12-31
中文摘要
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英文摘要
The human calcium sensing receptor (CaSR) has been targeted therapeutically in hyperparathyroidism and osteoporosis, but current CaSR therapeutics exhibit problematic side effects or are ineffective. Thus, the current research proposal seeks to understand the specific properties of CaSR drugs required to selectively control whole body calcium and bone mineral metabolism, to identify ligands that can mediate desired therapeutic effects at the exclusion of adverse effects.
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会议论文
Bias and allostery at the calcium sensing receptor
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批准号：FT160100075
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项目类别：ARC Future Fellowships
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资助金额：$44.88万
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财政年份：2017
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负责人：Dr Katie Leach
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依托单位：
Stabilising biased allosteric G protein-coupled receptor conformations
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批准号：DP170104228
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项目类别：Discovery Projects
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资助金额：$25.58万
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财政年份：2017
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负责人：Dr Katie Leach
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依托单位：
Engendering biased signalling at the human calcium sensing receptor (CaSR) to correct pathophysiology
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批准号：nhmrc : GNT1085143
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项目类别：Project Grants
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资助金额：$61.42万
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财政年份：2015
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负责人：Dr Katie Leach
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依托单位：
Allosteric modulation and biased signalling at the calcium-sensing receptor
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批准号：nhmrc : 1026962
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项目类别：Project Grants
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资助金额：$42.42万
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财政年份：2012
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负责人：Dr Katie Leach
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依托单位：
海外基金
