Stabilising biased allosteric G protein-coupled receptor conformations

该项目旨在开发和鉴定能够稳定不同钙敏感受体(CaSR)构象的分子。CaSR是脊椎动物赖以生存的G蛋白偶联受体。GPCRs几乎负责所有(病理)生理过程。它们在结构上非常灵活，但这阻碍了它们在结构上的决心。开发和验证所提出的分子应该有助于未来对重要的GPCR的结构研究。该项目希望加强对CASR结构和功能的了解，并最终了解GPCR超家族，这最终将带来发现新药的机会。

This project aims to develop and identify molecules that can stabilise distinct calcium sensing receptor (CaSR) conformations. The CaSR is a G protein-coupled receptor (GPCR) vertebrates need to live. GPCRs are responsible for virtually all (patho)physiological processes. They are structurally very flexible, but this has hindered their structural determination. Developing and validating the proposed molecules should help future structural studies of an important GPCR. The project expects to enhance understanding of the structure and function of the CaSR and ultimately of the GPCR superfamily, which will ultimately lead to opportunities to discover new drugs.