Altered Myelin Sphingolipid Homeostasis in Alzheimer's Disease

阿尔茨海默病中髓磷脂鞘脂稳态的改变

• 批准号: nhmrc : 1024966
• 负责人: A/Pr Anthony Don
• 金额: $ 41.98万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/altered-myelin-sphingolipid-alzheimers-disease/110393
• 关键词: Altered; Myelin; Sphingolipid; Homeostasis; Alzheimer

Alzheimer’s Disease (AD) is the most common form of dementia, and its incidence is rising as the population ages. This project will provide a detailed analysis and explanation for the loss of particular lipid (fat) molecules that are essential for myelin integrity, in the brains of AD patients. Myelin is the insulating layer that surrounds brain cells, facilitating the transmission of electrical signals. This research will improve our understanding of how brain functions are impaired in AD.

阿尔茨海默病(AD)是最常见的痴呆症，其发病率随着人口老龄化而上升。该项目将为AD患者大脑中对髓鞘完整性至关重要的特定脂(脂肪)分子的丢失提供详细的分析和解释。髓鞘是包围脑细胞的绝缘层，促进电信号的传递。这项研究将提高我们对阿尔茨海默病大脑功能受损的理解。