Understanding sphingolipid mediators of insulin resistance

了解胰岛素抵抗的鞘脂介质

• 批准号: nhmrc : 1126135
• 负责人: A/Pr Anthony Don
• 金额: $ 43.91万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-sphingolipid-mediators-insulin-resistance/947737
• 关键词: Understanding; sphingolipid; mediators; insulin; resistance

Sphingolipids are a class of lipid metabolites that have a variety of functions within cells. It has been known for some time that an accumulation of excess lipid, including certain sphingolipids, can adversely impact insulin action and glucose metabolism in cells. In this project we will a combination of strategies to test the hypothesis that the sphingolipid profile can be manipulated to have favourable effects on metabolism.

鞘脂是一类脂质代谢物，在细胞内具有多种功能。一段时间以来，人们已经知道，包括某些鞘脂在内的过量脂质积累会对细胞中的胰岛素作用和葡萄糖代谢产生不利影响。在这个项目中，我们将结合多种策略来测试鞘脂谱可以被操纵以对代谢产生有利影响的假设。