Restoring neuroprotective sphingosine 1-phosphate signalling in Alzheimer’s Disease

恢复阿尔茨海默病中的神经保护性鞘氨醇 1-磷酸信号传导

• 批准号: nhmrc : GNT1100626
• 负责人: A/Pr Anthony Don
• 金额: $ 85.77万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/restoring-neuroprotective-sphingosine-alzheimers-disease/1346129
• 关键词: Restoring; neuroprotective; sphingosine; phosphate; signalling

Our research team has recently shown that a vital signalling lipid called S1P is lost from the brains of people who are in the early stages of developing Alzheimer's Disease. S1P protects brain cells against toxic insults that cause Alzheimer's Disease. This project will investigate how loss of S1P sensitizes people to the development of Alzheimer’s Disease, and the effectiveness of clinical drugs that restore S1P signals in protecting against Alzheimer’s Disease and restoring brain function.

我们的研究小组最近表明，一种名为S1P的重要信号脂质从处于阿尔茨海默病早期阶段的人的大脑中丢失。S1P保护脑细胞免受导致阿尔茨海默病的毒性损伤。该项目将研究S1P的丧失如何使人们对阿尔茨海默病的发展敏感，以及恢复S1P信号的临床药物在预防阿尔茨海默病和恢复脑功能方面的有效性。