Amyloid precursor proteins novel role in Alzheimers disease through regulating neuronal iron homeostasis.

淀粉样前体蛋白通过调节神经元铁稳态在阿尔茨海默病中发挥新作用。

• 批准号: nhmrc : 566827
• 负责人: A/Pr Robert Moir
• 金额: $ 63.32万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/amyloid-precursor-proteins-iron-homeostasis/100217
• 关键词: Amyloid; precursor; proteins; novel; role

Our group has discovered a novel role of amyloid precursor protein (APP) in cellular iron balance. The smallest form of APP, prevalently found in the brain, is able to convert a damaging iron variety (Fe2+) into the safer Fe3+. Alternative, larger, forms of APP are found to inhibit this effect. This project will establish how APP controls iron homeostasis within brain neuronal cells and how this activity is impaired in disease, thus development a mechanism for diagnostic tests and therapeutics.

我们的小组发现了淀粉样前体蛋白（APP）在细胞铁平衡中的新作用。APP的最小形式，通常在大脑中发现，能够将有害的铁（Fe2+）转化为更安全的Fe3+。发现替代的较大形式的APP抑制这种效应。该项目将确定APP如何控制脑神经元细胞内的铁稳态，以及这种活性如何在疾病中受损，从而开发诊断测试和治疗的机制。