Rationale for non-invasive treatment of Retinopathy of Prematurity: Dark Rearing as a means of mimicking physiological vascularisation

非侵入性治疗早产儿视网膜病的基本原理：黑暗饲养作为模仿生理血管化的一种手段

• 批准号: nhmrc : 1005730
• 负责人: Prof Tailoi Chan-Ling
• 金额: $ 27.6万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/rationale-non-invasive-physiological-vascularisation/109108
• 关键词: Rationale; non; invasive; treatment; Retinopathy

We aim to develop a new, non-invasive and cost-effective treatment for the disease Retinopathy of Prematurity, the leading cause of childhood blindness across the globe. We intend to test our hypothesis that raising neonates in conditions of total darkness and high oxygen will closely mimic conditions for inducing normal retinal vascular development, and thus prevent the initiating event of the disease. Ultimately, the project intends to lay the groundwork for a translation to the human condition.

我们的目标是开发一种新的，非侵入性和成本效益的治疗疾病视网膜病变的早产儿，主要原因是儿童失明的地球仪。我们打算检验我们的假设，即在完全黑暗和高氧的条件下养育新生儿将密切模拟诱导正常视网膜血管发育的条件，从而防止疾病的起始事件。最终，该项目旨在为人类状况的翻译奠定基础。