REACH: Randomised trial of EArly Rehabilitation in Congenital Hemiplegia

患有不对称性脑损伤的婴儿是先天性偏瘫的高危人群。这项研究对150名3-6个月的婴儿进行了改良的CIMT和相同剂量的双指甲训练的比较。这两种疗法都将在经验丰富的临床医生的支持下由父母提供。结果包括在双手操作中使用受损的手，在12个月和24个月的C.A.时认知和运动发育。在24个月时测量神经结构和功能连通性。早期干预，使病情减轻

Infants with asymmetric brain lesions are at high risk of congenital hemiplegia. This study compares modified CIMT to an equal dose of bimanual training in 150 infants recruited at 3-6 months. Both therapies will be parent-delivered supported by experienced clinicians. Outcomes include use of the impaired hand in bimanual tasks, cognitive and motor development at 12 and 24 months c.a. with measures of neural structure and functional connectivity at 24 months. Early interventions that attenuate