Real-time optical window imaging of AKT-FRET biosensor mice to maximise PI3K/AKT drug targeting within the hypoxic microenvironment of pancreatic cancer.

点击翻译按钮获取中文摘要

Inefficient drug response in solid tumour tissue is often a limiting factor in the clinical effectiveness of cancer therapies. Using cutting-edge imaging technology and 3D models that mimic the disease, we have mapped areas of poor drug response within distinct regions of tumours with low oxygen levels known as hypoxia. Here, we will specifically target factors limiting efficient drug targeting in these areas to improve the encouraging anti-cancer profile of AKT inhibitors in pancreatic cancer.