Single-cell optical window imaging in CDK1-FRET biosensor mice to assess tissue stiffness and optimise delivery and therapeutic response to Gemcitabine/Abraxane in pancreatic cancer.

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Inefficient drug response in solid tumour tissue is commonly a limiting factor in the clinical effectiveness of cancer therapies. Using cutting-edge imaging technology and 3D models that mimic the disease, we have mapped areas of poor drug response within distinct regions of tumours. Here, we pinpoint and specifically target key factors limiting efficient drug targeting in order to improve the encouraging anti-cancer profile of the new drug combination Gemcitabine/Abraxane in pancreatic cancer.