Recognition of lipid antigens by CD1d-restricted Type-2 NKT cells

CD1d 限制的 2 型 NKT 细胞对脂质抗原的识别

• 批准号: nhmrc : GNT1083885
• 负责人: Dr Daniel Pellicci
• 金额: $ 26.93万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/recognition-lipid-antigens-nkt-cells/1345528
• 关键词: Recognition; lipid; antigens; CD1d; restricted

Protection against infection depends on T cells, which recognise and target foreign molecules called antigens via a specialized antigen receptor known as a T cell receptor (TCR). This project focuses on a specialised population of T cells called Natural Killer T (NKT) cells that recognise lipid antigens. The work outlined in this grant will increase our understanding of how different TCRs can recognise diverse lipid antigens thus providing insight into the role of NKT cells in the immune system.

针对感染的保护依赖于T细胞，T细胞通过称为T细胞受体（TCR）的专门抗原受体识别并靶向称为抗原的外来分子。该项目的重点是一种称为自然杀伤T（NKT）细胞的专门T细胞群，它识别脂质抗原。这项资助概述的工作将增加我们对不同TCR如何识别不同脂质抗原的理解，从而深入了解NKT细胞在免疫系统中的作用。