Recognition of lipid antigens by the immune system.

免疫系统对脂质抗原的识别。

• 批准号: FT140100278
• 负责人: Dr Adam Uldrich
• 金额: $ 53.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140100278
• 关键词: Recognition; lipid; antigens; immune; system.

T cells are a critical component of the immune system, protecting against a range of pathogens by detecting and responding to foreign molecules. Despite their importance, there is still much to learn about how T cells function. New types of T cells that respond to bacteria-derived lipid molecules, have recently been identified. This project aims to undertake a molecular and functional investigation into lipid-reactive T cells. This will provide basic fundamental insight into a poorly understood, but crucial, component of the immune system as well as an opportunity to ultimately develop novel lipid-based vaccines.

T细胞是免疫系统的重要组成部分，通过检测和响应外来分子来抵御一系列病原体。尽管它们很重要，但关于T细胞如何发挥作用还有很多东西需要了解。最近已经鉴定了对细菌衍生的脂质分子做出反应的新型T细胞。该项目旨在对脂质反应性T细胞进行分子和功能研究。这将为免疫系统的一个知之甚少但至关重要的组成部分提供基本的基本见解，并为最终开发新型脂质疫苗提供机会。