The role of CD1-restricted T cells in health and disease

CD1 限制性 T 细胞在健康和疾病中的作用

• 批准号: nhmrc : GNT1144308
• 负责人: Dr Daniel Pellicci
• 金额: $ 43.1万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-cd1-restricted-health-disease/1348604
• 关键词: role; CD1; restricted; cells; health

The human immune system requires T cells for survival. Specialised populations of T cells exist that patrol the body and target unwanted lipid molecules expressed by bacteria or by cells that have become abnormal or cancerous. I will identify these T cells in human blood and skin and determine their role in protection against disease. I will explore the types of lipids molecules recognised by these T cells and use this information to help prevent human diseases.

人类免疫系统需要T细胞才能生存。专门的T细胞群在体内巡逻，瞄准由细菌或异常或癌变的细胞表达的不需要的脂质分子。我将识别人类血液和皮肤中的这些T细胞，并确定它们在预防疾病方面的作用。我将探索这些T细胞识别的脂质分子的类型，并利用这些信息来帮助预防人类疾病。