Redox Control of the Immune Regulatory Protein, Indoleamine 2,3-dioxygenase

免疫调节蛋白吲哚胺 2,3-双加氧酶的氧化还原控制

• 批准号: nhmrc : 1058508
• 负责人: A/Pr Paul Witting
• 金额: $ 38.44万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/redox-control-immune-23-dioxygenase/454679
• 关键词: Redox; Control; Immune; Regulatory; Protein

An enzyme called indoleamine 2,3-dioxygenase is important for controlling the immune system during normal and disease conditions including pregnancy, cancer, inflammation and infectious disease. Despite its importance little is known about how this enzyme is controlled. This project will provide important new insights into how this enzyme is regulated. Such fundamental scientific information can discover new ways in which to alter the enzyme's activity in order to modulate immune responses.

一种称为吲哚胺2，3-双加氧酶的酶对于在正常和疾病条件下控制免疫系统非常重要，包括怀孕，癌症，炎症和传染病。尽管它的重要性很少有人知道如何控制这种酶。该项目将提供重要的新见解，了解这种酶是如何调节的。这些基础科学信息可以发现改变酶活性以调节免疫反应的新方法。