Studies into Myeloperoxidase-Induced Cardiovascular Disease and its Treatment

髓过氧化物酶诱发的心血管疾病及其治疗的研究

• 批准号: nhmrc : GNT1125392
• 负责人: A/Pr Paul Witting
• 金额: $ 92.46万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/studies-myeloperoxidase-induced-disease-treatment/1347478
• 关键词: Studies; into; Myeloperoxidase; Induced; Cardiovascular

During cardiovascular disease an inflammatory protein called myeloperoxidase (MPO) becomes abnormally released into the circulating blood and is transported into diseased blood vessels. Our studies show for the first time that increasing circulating levels of MPO promotes both atherosclerosis and aortic aneurysm. This project will study how MPO promotes inflammatory artery disease and test new drugs for their ability to inhibit this damaging protein and protect against cardiovascular disease.

在心血管疾病期间，称为髓过氧化物酶（MPO）的炎性蛋白质异常释放到循环血液中并被运送到患病的血管中。我们的研究第一次表明，MPO循环水平的增加促进动脉粥样硬化和主动脉瘤。该项目将研究MPO如何促进炎症性动脉疾病，并测试新药抑制这种破坏性蛋白质和预防心血管疾病的能力。