The alternate renin angiotensin system; a novel target for the prevention and treatment of liver fibrosis and portal hypertension

替代肾素血管紧张素系统；

• 批准号: nhmrc : 1062372
• 负责人: Dr Chandana Herath
• 金额: $ 46.27万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/alternate-renin-angiotensin-portal-hypertension/454985
• 关键词: alternate; renin; angiotensin; system; novel

Cirrhosis of the liver due to chronic hepatitis and other common liver diseases is now a major cause of illness and death in Australia. This project will examine how a hormone system called the renin angiotensin system contributes to the development of liver damage in these diseases. We will study whether drugs targeting this system can be used to reduce liver scarring and prevent the development of cirrhosis and its complications.

由于慢性肝炎和其他常见肝病引起的肝硬化现在是澳大利亚疾病和死亡的主要原因。这个项目将研究一种称为肾素血管紧张素系统的激素系统如何促进这些疾病中肝损伤的发展。我们将研究靶向该系统的药物是否可用于减少肝瘢痕形成和预防肝硬化及其并发症的发展。