Targeting the renin angiotensin system in liver fibrosis and portal hypertension

靶向肾素血管紧张素系统治疗肝纤维化和门静脉高压

• 批准号: nhmrc : 1008252
• 负责人: Dr Chandana Herath
• 金额: $ 42.94万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-renin-angiotensin-portal-hypertension/109291
• 关键词: Targeting; renin; angiotensin; system; liver

Cirrhosis of the liver due to chronic hepatitis and other common liver diseases is now a major cause of illness and death in Australia. This project will examine how a hormone system called the renin angiotensin system contributes to the development of liver damage in these diseases. We will study whether drugs targeting this system can be used to reduce liver scarring and prevent the development of cirrhosis and its complications.

慢性肝炎和其他常见肝病导致的肝硬变现在是澳大利亚疾病和死亡的主要原因。这个项目将研究一种名为肾素血管紧张素系统的激素系统如何在这些疾病中促进肝脏损伤的发展。我们将研究是否可以使用针对该系统的药物来减少肝脏瘢痕形成，防止肝硬变及其并发症的发展。