An integrated approach to combat antibiotic resistance

青霉素等抗生素的开发被誉为医学上的重大突破之一。然而，越来越多的病原体对这些药物产生了耐药性。这些病原体采用的最常见的耐药机制之一是使用促进抗生素降解的金属依赖性酶。到目前为止，还没有临床上有用的这些酶的抑制剂。在这个项目中，我们的目标是开发这种抑制剂作为治疗药物先导。

The development of antibiotics such as penicillin was hailed as one of the great breakthroughs in medicine. However, an increasing number of pathogens have acquired resistance to these drugs. One of the most common resistance mechanisms employed by these pathogens is the use of metal dependent enzymes that promote the degradation of antibiotics. To date, no clinically useful inhibitors for these enzymes are available. In this project, we aim to develop such inhibitors as therapeutic drug leads.