THE AUTONOMIC, SOMATIC AND CENTRAL NEURAL RESPONSES TO DEEP AND SUPERFICIAL PAIN IN HUMAN SUBJECTS

人类受试者对深部和浅表疼痛的自主、躯体和中枢神经反应

• 批准号: nhmrc : 350889
• 负责人: A/Pr Luke Henderson
• 金额: $ 25.06万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/autonomic-somatic-central-human-subjects/98952
• 关键词: AUTONOMIC; SOMATIC; CENTRAL; NEURAL; RESPONSES

Pain is a subjective experience, the intensity of which can be readily influenced by personal experience. Despite this, pain originating from a particular part of the body will usually be described by all individuals as having similar character. For example, pain arising from the skin is commonly described as being sharp or burning and is usually easy to localise, whereas pain arising from muscle is commonly dull, throbbing and diffuse. In addition to producing sensory changes, pain also evokes changes in blood pressure, heart rate and motor activity (often in an attempt to remove the source of the pain). The proposed research aims to characterise the cardiovascular and motor patterns associated with pain originating in skin and in muscle and to examine the brain regions that produce these changes. More specifically, microelectrodes will be used to investigate changes in peripheral nerve activity during transient painful skin and muscle events in awake human subjects. In a separate investigation functional magnetic resonance imaging will be used to determine brain sites that are activated by skin or muscle pain.

疼痛是一种主观体验，其强度很容易受到个人经验的影响。尽管如此，来自身体特定部位的疼痛通常会被所有人描述为具有相似的特征。例如，由皮肤引起的疼痛通常被描述为尖锐或烧灼感，并且通常容易定位，而由肌肉引起的疼痛通常是迟钝的，悸动的和扩散的。除了产生感觉变化外，疼痛还会引起血压、心率和运动活动的变化（通常是为了消除疼痛的来源）。这项研究旨在研究与皮肤和肌肉疼痛相关的心血管和运动模式，并检查产生这些变化的大脑区域。更具体地说，微电极将用于研究清醒人类受试者在短暂疼痛皮肤和肌肉事件期间外周神经活动的变化。在一项单独的研究中，功能性磁共振成像将用于确定皮肤或肌肉疼痛激活的大脑部位。