The cause of undescended testis and inguinal hernia

睾丸未降和腹股沟疝的原因

• 批准号: nhmrc : GNT1144752
• 负责人: Dr Bridget Southwell
• 金额: $ 74.38万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cause-undescended-testis-inguinal-hernia/1348631
• 关键词: cause; undescended; testis; inguinal; hernia

This study aims to define in both animal models and children how the testis descends from the abdomen to scrotum, and how undescended testis and inguinal hernia are likely to be caused by defects in the same, very indirect signalling pathway. The results will demonstrate where to look for genetic causes and proof of principle for possible future medical treatments for the 3 commonest major operations in children for congenital and acquired undescended testis and inguinal hernia.

本研究的目的是在动物模型和儿童中确定睾丸如何从腹部下降到阴囊，以及隐睾和腹股沟疝如何可能由相同的非常间接的信号通路缺陷引起。研究结果将证明在哪里寻找遗传原因，并为未来可能的医学治疗提供原则证据，用于先天性和后天性隐睾和腹股沟疝儿童3种最常见的大手术。