The optimal operation time of undescended testes is studied inrelation to Fas gene expression in experimental cryptorchid testis

研究隐睾实验中隐睾最佳手术时间与Fas基因表达的关系

• 批准号: 14370567
• 负责人: SHONO Takeshi
• 金额: $ 8.7万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370567/
• 关键词: Undescended testis; Apoptosis; Fas; Endocine disruptos; Fertility

To decide opti, altime for the corrective surgery of undescended testis six experimental models of crtptorchdism were made.These models were, untra-abdominal testis, inguinal testis, perineal testis, ascending testis, flutamide-induced undescended testis, phthalate-induced undescended testis.The results suggested that in all of these rat models, both apoptotic cells and Fas positive germ cells were significantly increased in testes of postpubertal rats than t hose of prepubertal rats. Especially in both flutamide-induced and phthalate-induced undescended testis histological changes were severer than those of mechanically induced underdescended testes.The rats which welt performed orchiopexy before pubertal got better fertility function than that of rats which were performed orchiopexy after puberty in all experimental models.

为了确定隐睾矫正手术的最佳时机，我们制作了六种隐睾症实验模型：腹下睾丸模型、腹股沟睾丸模型、会阴睾丸模型、升睾丸模型、氟他胺诱导的隐睾模型、邻苯二甲酸酯诱导的隐睾模型。结果表明，在所有这些大鼠模型中，青春期后大鼠睾丸中凋亡细胞和Fas阳性生殖细胞均明显多于青春期前大鼠。尤其是氟他胺和邻苯二甲酸酯诱导的隐睾组织学改变均比机械诱导的隐睾组织学改变更明显。在所有实验模型中，青春期前行睾丸固定的大鼠生育功能均优于青春期后行睾丸固定的大鼠。

项目成果

Disturbed pituitary-testicular axis inhibits testicular descent in prenatal stress rat

垂体-睾丸轴紊乱抑制产前应激大鼠睾丸下降

• 发表时间: 2003
• 期刊: B J U international 92
• 作者: Shono T.;Suita S
• 通讯作者: Suita S

Tajiri T, Shono K, Tanaka S, Suita S: "Evaluation of genetic heterogeneity in neuroblastoma"Surgery. 131. S283-S287 (2002)

Tajiri T、Sono K、Tanaka S、Suita S：“神经母细胞瘤遗传异质性的评估”手术。

Shono T., Suita S: "Disturbed pituitary-testicular axis inhibits testicular descent in prenatal stress rat"B J U international. 92. 641-644 (2003)

Shono T.，Suita S：“垂体-睾丸轴紊乱抑制产前应激大鼠睾丸下降”B J U International。

Shono T, Kai H, Suita S: "Ectopic Renal Tissue in the Gubernaculum Associated with Undescended Testis"B J U international. 89. 321-321 (2002)

Shono T、Kai H、Suita S：“与未降睾丸相关的引带异位肾组织”B J U 国际。

Long-term effects of intrauterine mono-n-butyl phthalate on the reproductive function of the postnatal rats.

宫内注射邻苯二甲酸单丁酯对产后大鼠生殖功能的长期影响。

• 发表时间: 2005
• 期刊: Journal of Pediatric Surgery. 40
• 作者: Kai H.Shono T.Tajiri T.Suita S.