The optimal operation time of undescended testes is studied inrelation to Fas gene expression in experimental cryptorchid testis

为选择合适的手术时机，制作了6个隐睾实验模型。这些模型分别是腹外睾丸、腹股沟睾丸、会阴睾丸、上升睾丸、氟他胺诱导的隐睾、邻苯二甲酸盐诱导的隐睾。结果表明，在所有大鼠模型中，青春期后大鼠睾丸凋亡细胞和Fas阳性生殖细胞均明显高于青春期前大鼠。特别是氟他胺诱导和邻苯二甲酸盐诱导下降睾丸的组织学改变均比机械诱导下降睾丸严重。在各实验模型中，青春期前行睾丸切除术的大鼠的生育功能均优于青春期后行睾丸切除术的大鼠。

To decide opti, altime for the corrective surgery of undescended testis six experimental models of crtptorchdism were made.These models were, untra-abdominal testis, inguinal testis, perineal testis, ascending testis, flutamide-induced undescended testis, phthalate-induced undescended testis.The results suggested that in all of these rat models, both apoptotic cells and Fas positive germ cells were significantly increased in testes of postpubertal rats than t hose of prepubertal rats. Especially in both flutamide-induced and phthalate-induced undescended testis histological changes were severer than those of mechanically induced underdescended testes.The rats which welt performed orchiopexy before pubertal got better fertility function than that of rats which were performed orchiopexy after puberty in all experimental models.