Postnatal germ cells are controlled by FSH during 'minipuberty' at 3-6 months, and deranged by cryptorchidism to cause seminoma and infertility

出生后生殖细胞在 3-6 个月的“小青春期”期间受 FSH 控制，并因隐睾紊乱而导致精原细胞瘤和不育

• 批准号: nhmrc : GNT1127109
• 负责人: Dr Bridget Southwell
• 金额: $ 81.37万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/postnatal-germ-cells-seminoma-infertility/1347598
• 关键词: Postnatal; germ; cells; controlled; FSH

This study will investigate the exciting possibility that the risk of cancer and infertility in adulthood in infants born with undescended testes might be obviated by understanding how primitive sperm cells behave in the postnatal testis. The study will define the key changes to the primitive sperm cells, including their timing and control by hormones, so surgery is done at the right time +/-accessory hormone treatment to optimise future sperm function for babies with undescended testes.

这项研究将探讨一种令人兴奋的可能性，即通过了解原始精子细胞在出生后睾丸中的行为，可以避免患有隐睾症的婴儿成年后患癌症和不孕症的风险。这项研究将确定原始精子细胞的关键变化，包括它们的时间和激素的控制，因此手术是在正确的时间进行+/-辅助激素治疗，以优化未来的精子功能，为隐睾婴儿。