The contribution of aberrant Wnt signalling to neuronal and vascular pathology in retinal disease

异常 Wnt 信号传导对视网膜疾病神经元和血管病理学的影响

• 批准号: nhmrc : 1050373
• 负责人: Dr Ling Zhu
• 金额: $ 37.43万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/contribution-aberrant-wnt-retinal-disease/112150
• 关键词: contribution; aberrant; Wnt; signalling; neuronal

Neuronal damage and vascular abnormalities are features shared by many retinal diseases. We will use a novel transgenic model to study the contributions of aberrant Wnt signalling in retinal neuronal and vascular pathology, and also, to test strategies for neuroprotection and inhibition of vascular abnormalities. Success in the project may identify novel therapeutic targets leading to safer and more effective treatments for retinal diseases.

神经元损伤和血管异常是许多视网膜疾病共有的特征。我们将使用一种新的转基因模型来研究异常Wnt信号在视网膜神经元和血管病理中的作用，并测试神经保护和抑制血管异常的策略。该项目的成功可能会发现新的治疗靶点，从而为视网膜疾病提供更安全，更有效的治疗方法。