Targeting the de novo serine synthesis pathway in macular disease

靶向黄斑疾病中的丝氨酸从头合成途径

• 批准号: nhmrc : 1145121
• 负责人: Dr Ling Zhu
• 金额: $ 42.47万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-novo-serine-macular-disease/1320358
• 关键词: Targeting; de; novo; serine; synthesis

We have found a significant difference in de novo serine metabolism between the human primary Müller cells isolated from macular and peripheral retinas. We will study whether and how this difference contributes to redox homeostasis in these areas. The outcomes will help us to gain a better understanding of why the macula is more prone to develop disease than the peripheral retina.

我们已经发现从黄斑和外周视网膜分离的人原代Müller细胞之间的从头丝氨酸代谢存在显著差异。我们将研究这种差异是否以及如何有助于这些领域的氧化还原稳态。这些结果将帮助我们更好地了解为什么黄斑比周边视网膜更容易发生疾病。