The control of autoimmunity originating from somatically hypermutated B cells

对源自体细胞超突变 B 细胞的自身免疫的控制

• 批准号: nhmrc : 1080387
• 负责人: Dr Tyani Chan
• 金额: $ 35.36万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-autoimmunity-originating-b-cells/518741
• 关键词: control; autoimmunity; originating; somatically; hypermutated

Our immune systems are capable of producing long-lived antibodies that can last a lifetime. Sometimes, this powerful process can however become abnormal and result in autoimmune diseases such as lupus. We have recently developed the first experimental mouse model that allows researchers to study this process in great detail. This funding will extend our initial observations by identifying the exact mechanisms by which important regulators of autoimmune disease act.

我们的免疫系统能够产生可以持续一生的长效抗体。然而，有时，这个强大的过程可能会变得异常，并导致狼疮等自身免疫性疾病。我们最近开发了第一个实验小鼠模型，使研究人员能够详细研究这一过程。这笔资金将通过确定自身免疫性疾病重要调节因子发挥作用的确切机制来扩展我们的初步观察。