Regulation of the production of IgE antibodies by antigen-specific B cells

抗原特异性 B 细胞调节 IgE 抗体的产生

• 批准号: nhmrc : 1054669
• 负责人: Dr Tyani Chan
• 金额: $ 22.05万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-production-ige-b-cells/112410
• 关键词: Regulation; production; IgE; antibodies; antigen

Our team has been studying the immune cells that make antibodies and recently discovered that cells without a particular gene make large amounts of IgE antibody. IgE is responsible for asthma and other allergies, which are a major cause of morbidity in the Western world. Based on this discovery, we aim to find out exactly how and why IgE is made in some circumstances but not others, and what other immune cells are involved. These results will identify a way to prevent asthma and other allergies.

我们的团队一直在研究产生抗体的免疫细胞，最近发现没有特定基因的细胞会产生大量的IgE抗体。IgE是哮喘和其他过敏的原因，这是西方世界发病的主要原因。基于这一发现，我们的目标是找出究竟如何以及为什么IgE是在某些情况下，而不是其他人，以及其他免疫细胞参与。这些结果将确定一种预防哮喘和其他过敏的方法。