The effect of innate immune responses on the induction of protective immunity in murine typhoid fever

先天免疫反应对鼠伤寒保护性免疫诱导的影响

• 批准号: nhmrc : 251695
• 负责人: Prof Richard Strugnell
• 金额: $ 9.1万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-innate-immune-typhoid-fever/95997
• 关键词: effect; innate; immune; responses; induction

Salmonella are important pathogens of humans causing diseases ranging from gastroenteritis, typhoid fever to arthritis. Like most if not all infections, the early interaction between the host and the bacterium is characterised by very non-specific symptoms. These non-specific symptoms arise because the so-called innate immune system is activated by the infection. The purpose of this grant is to establish whether these non-specific symptoms, caused by the release of immunological homrones called cytokines, are essential to the development of an effective immune response which can protect against subsequent re-infection. This study has important implications for vaccines, of our understanding of how bacteria cause disease, and the role-capacity of the innate immune system in the development of immunity.

沙门氏菌是人类的重要病原体，可引起胃肠炎、伤寒和关节炎等多种疾病。像大多数感染一样，宿主和细菌之间的早期相互作用的特征是非常非特异性的症状。这些非特异性症状的出现是因为所谓的先天免疫系统被感染激活。这项资助的目的是确定这些非特异性症状是否是由称为细胞因子的免疫同源物释放引起的，对于有效免疫应答的发展至关重要，这种免疫应答可以防止随后的再感染。这项研究对疫苗，我们对细菌如何引起疾病的理解以及先天免疫系统在免疫发展中的作用能力具有重要意义。