Function and molecular mechanism of histidine-rich glycoprotein in necrotic cell and pathogen clearance

富含组氨酸糖蛋白在坏死细胞和病原体清除中的功能和分子机制

• 批准号: nhmrc : GNT1082383
• 负责人: A/Pr Marc Kvansakul
• 金额: $ 50.95万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/function-molecular-mechanism-pathogen-clearance/1345458
• 关键词: Function; molecular; mechanism; histidine; rich

This research proposal is to investigate the molecular mechanism and function of a blood serum protein, histidine-rich glycoprotein (HRG), in protecting against tissue injury caused by inflammation and infection. HRG has been implicated in controlling important aspects of tissue injury by aiding removal of dead cells and pathogens. Understanding the role of HRG in these disease settings may allow the development of approaches for the treatment of inflammatory, autoimmune and infectious disease.

本研究旨在探讨血清蛋白富含组氨酸糖蛋白(HRG)对炎症和感染引起的组织损伤保护作用的分子机制和功能。HRG通过帮助清除死亡细胞和病原体来控制组织损伤的重要方面。了解HRG在这些疾病环境中的作用可能有助于开发治疗炎症性、自身免疫性和感染性疾病的方法。