The generation and function of tissue-specific regulatory T cells

组织特异性调节性T细胞的产生和功能

• 批准号: nhmrc : 508900
• 负责人: Prof Ian Van Driel
• 金额: $ 32.58万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/generation-function-tissue-t-cells/76550
• 关键词: generation; function; tissue; specific; regulatory

The immune system normally protects against invasion by pathogens such as harmful viruses and bacteria. In autoimmune diseases the same mechanisms that are used to protect us are erroneously targeted to our own tissues. We will discover how regulatory lymphocytes, are able to protect against autoimmune disease. Such regulatory lymphocytes are attractive therapeutic agents to prevent a variety of immune-mediated diseases, including autoimmune diseases, allergy and transplantation rejection.

免疫系统通常会防御有害病毒和细菌等病原体的入侵。在自身免疫性疾病中，用于保护我们的相同机制错误地针对我们自己的组织。我们将发现调节性淋巴细胞是如何预防自身免疫性疾病的。这类调节性淋巴细胞是一种很有吸引力的治疗药物，可以预防各种免疫介导性疾病，包括自身免疫性疾病、过敏和移植排斥反应。