Regulated intracellular trafficking of a potassium channel in gastric acid-secreting cells

调节胃酸分泌细胞中钾通道的细胞内运输

• 批准号: nhmrc : 1008617
• 负责人: Prof Ian Van Driel
• 金额: $ 40.64万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulated-intracellular-trafficking-secreting-cells/109329
• 关键词: Regulated; intracellular; trafficking; potassium; channel

The cells of our bodies possess proteins that transport salts and other chemicals. These transport proteins must be correctly positioned in cells, a process that is poorly understood. If transport proteins are not positioned properly then diseases such as heart attack or diabetes may occur. Influencing the position of transport proteins may also be used to treat disease. This work investigates how a transport protein that shuttles potassium is correctly positioned in cells of the stomach.

我们身体的细胞拥有运输盐和其他化学物质的蛋白质。这些转运蛋白必须在细胞中正确定位，但人们对这一过程知之甚少。如果转运蛋白定位不正确，则可能会发生心脏病或糖尿病等疾病。影响转运蛋白的位置也可用于治疗疾病。这项工作研究了转运钾的转运蛋白如何正确定位在胃细胞中。