The role of the gastric H/K ATPase in parietal cell function

胃 H/K ATP 酶在壁细胞功能中的作用

• 批准号: nhmrc : 124338
• 负责人: Prof Ian Van Driel
• 金额: $ 11.13万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-gastric-hk-cell-function/96350
• 关键词: role; gastric; ATPase; parietal; cell

The cells of the body contain many specialised membrane structures. At present it is not clear how the synthesis of these stuctures is directed. To study this problem we are examining the acid secretory parietal cells of the stomach. These cells have a very elaborate membrane system that contains a major proton pump protein. By manipulating the levels and form of the proton pump we will gain novel insights into the mechanism of membrane structure and function.

身体的细胞包含许多专门的膜结构。目前还不清楚这些结构的合成是如何指导的。为了研究这个问题，我们正在研究胃酸分泌的胃壁细胞。这些细胞有一个非常复杂的膜系统，其中包含一个主要的质子泵蛋白。通过操纵质子泵的水平和形式，我们将获得膜结构和功能机制的新见解。