The genetics of ADHD: role of rare variants

注意力缺陷多动障碍（ADHD）是儿童期最常见的精神障碍，影响了澳大利亚约7.5%的学龄儿童。这种疾病具有很强的遗传性，会对学习功能、家庭和同伴关系造成重大损害，使患者滥用药物的风险增加。罕见突变的鉴定和表征将增强我们对神经生物学的了解，并促进对下一代药物治疗该疾病的研究。

Attention deficit hyperactivity disorde(ADHD) is the most prevalent mental disorder of childhood affecting around 7.5% of Australian school age children. The disorder is strongly genetic and causes significant impairments in academic functioning, family and peer relations with sufferers at increased risk for drug abuse. Identification and characterisation of rare mutations will enhance our knowledge of the neurobiology and advance the search for next generation drug treatments for the disorder.