The genetics of ADHD: role of rare variants

ADHD 的遗传学：罕见变异的作用

• 批准号: nhmrc : 1065677
• 负责人: A/Pr Alasdair Vance
• 金额: $ 43.47万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetics-adhd-role-rare-variants/455189
• 关键词: genetics; ADHD; role; rare; variants

Attention deficit hyperactivity disorde(ADHD) is the most prevalent mental disorder of childhood affecting around 7.5% of Australian school age children. The disorder is strongly genetic and causes significant impairments in academic functioning, family and peer relations with sufferers at increased risk for drug abuse. Identification and characterisation of rare mutations will enhance our knowledge of the neurobiology and advance the search for next generation drug treatments for the disorder.

注意缺陷多动障碍（ADHD）是儿童时期最普遍的精神障碍，影响了大约7.5%的澳大利亚学龄儿童。这种疾病具有很强的遗传性，会对学习功能、家庭和同伴关系造成严重损害，患者滥用药物的风险也会增加。罕见突变的识别和表征将增强我们对神经生物学的了解，并推进对下一代药物治疗这种疾病的研究。