Frontal-striatal-parietal activation in children with ADHD, combined type: a functional magnetic resonance imaging study

ADHD 儿童额叶-纹状体-顶叶激活，组合型：功能磁共振成像研究

• 批准号: nhmrc : 384419
• 负责人: A/Pr Alasdair Vance
• 金额: $ 6.12万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/frontal-striatal-parietal-imaging-study/82033
• 关键词: Frontal; striatal; parietal; activation; children

Attention Deficit Hyperactivity Disorder, combined type (ADHD-CT) is a common neuropsychiatric disorder that has serious consequences for affected children's educational and social development and success in later life. Despite a large investment in research investigating aetiology and therapeutic strategies that arise from these aetiological investigations, ADHD-CT remains poorly understood and it is often viewed with therapeutic pessimism. Understanding the neurobiological basis of ADHD-CT is of tremendous importance for the development of more specific and targeted medication and-or psychological treatments and, ultimately, to obtain the best clinical outcome for individual children with ADHD-CT. We have previously examined the function of frontal-striatal-parietal brain networks in adolescent boys with ADHD-CT, showing dysfunction of brain systems important for the control of visuospatial attention. In this project, we aim to examine whether these changes in frontal-striatal-parietal brain function also occur in pre-pubertal 8-12 year-old boys with ADHD-CT. This is important for two major reasons: Firstly, adolescents and young adults examined in previous brain imaging studies of ADHD-CT, including our own, are not truly representative of the core of the disorder, as ADHD-CT has its peak prevalence from 8 to 12 years of age. Secondly, by now comparing pre-pubertal ADHD-CT and healthy control children we can determine whether the changes in brain function we have previously identified represent developmental stage independent brain dysfunction that is characteristic of ADHD-CT.

联合型注意力缺陷多动障碍 (ADHD-CT) 是一种常见的神经精神疾病，对受影响儿童的教育和社会发展以及以后生活的成功产生严重后果。尽管对病因学和由这些病因学研究产生的治疗策略的研究投入了大量资金，但 ADHD-CT 仍然知之甚少，并且人们常常以治疗悲观态度看待它。了解 ADHD-CT 的神经生物学基础对于开发更具体和更有针对性的药物和/或心理治疗以及最终为患有 ADHD-CT 的个体儿童获得最佳临床结果至关重要。我们之前检查了患有 ADHD-CT 的青春期男孩的额叶-纹状体-顶叶大脑网络的功能，显示出对控制视觉空间注意力很重要的大脑系统功能障碍。在这个项目中，我们的目的是检查额叶-纹状体-顶叶大脑功能的这些变化是否也发生在患有 ADHD-CT 的青春期前 8-12 岁男孩中。这一点很重要，主要有两个原因：首先，在之前的 ADHD-CT 脑成像研究中检查的青少年和年轻人（包括我们自己的）并不能真正代表该疾病的核心，因为 ADHD-CT 的发病高峰期是 8 至 12 岁。其次，通过比较青春期前 ADHD-CT 和健康对照儿童，我们可以确定我们之前确定的脑功能变化是否代表了与发育阶段无关的脑功能障碍，这是 ADHD-CT 的特征。