The genitofemoral nerve and gubernaculum in testicular descent and inguinal hernia

睾丸下降和腹股沟疝气中的生殖股神经和结节

• 批准号: nhmrc : 284525
• 负责人: Prof John Hutson
• 金额: $ 22.65万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genitofemoral-nerve-gubernaculum-inguinal-hernia/96179
• 关键词: genitofemoral; nerve; gubernaculum; testicular; descent

This project examines the mechanism of descent of the testis, which when abnormal, leads to the common anomaly in infant boys of undescended testes. In addition, the tunnel through the abdominal wall which permits testicular descent very commonly fails to close afterwards, allowing the intestines to protrude through the hole to cause an inguinal hernia, which is a tender lump in the groin,and requires surgery to resolve. Our long-term aim is to understand testicular descent and inguinal closure well enough to develop non-surgical treatments for these two conditions, which are the two commonest abnormalities in children requiring surgery. We will examine how male hormones control descent of the testis indirectly by altering the anatomy and function of a specific nerve suplying the groin and scrotum. A simple and safe treatment that avoided surgery would be a major advance for infants in the developing world.

这个项目研究了睾丸下降的机制，当异常时，会导致未下降睾丸的男婴常见的异常。此外，通过腹壁的隧道允许睾丸下降后通常无法关闭，使肠道从洞中伸出导致腹股沟疝气，这是腹股沟的一个压痛性肿块，需要手术才能解决。我们的长期目标是充分了解睾丸下降和腹股沟关闭，以开发针对这两种疾病的非手术治疗方法，这两种疾病是需要手术的儿童中最常见的两种异常。我们将研究男性激素如何通过改变支配腹股沟和阴囊的特定神经的解剖和功能来间接控制睾丸的下降。对于发展中国家的婴儿来说，避免手术的简单安全的治疗将是一个重大进步。